Synthesis and Biological Activities of Substituted 7-Chloroquinoline Derivatives, Part I

Abstract

4-Hydroxy-7-chloroquinoline was treated with chloroacetic acid to get
an acid, which on esterification gave ester. Subsequently hydrazide
obtained was treated with aryl aldehydes to get hydrazones. 4,7-Dichloroquinoline
was condensed with methylanthranilate and hydrazide was
obtained using hydrazine hydrate. Hydrazones were synthesised using aryl
aldehydes. 4-Amino-7-chloroquinoline was condensed with anhydrides'
having active hydrogen. Imides thus obtained were treated with aryldiazonium
chloride to get hydrazone dyes.
7-Chloro-4-[4-methylidine-(aryl)-hydrazocarbonyl quinolinyloxy methane,
1-amino-(7-chloroquinoline)-2-[N-ethylidene-aryl] hydrazocarbonyl
benzene, 7 -chloro-4-[ 4-methy lidene-( aryl )-hydrazocarbonylquinolinyloxy-methane,
1-amino-(7 -chloroquinoline)-2-[N- methylidene-aryl]-hydrazocarbonyl
benzene.