Antitumour and Thermogravimetric Studies of Transition Metal Complexes of the Schiff Base Anthracene-9-Carboxaldehyde Thiosemicarbazone

Abstract

The complexes of transition metals with anthracene-9-carboxaldehyde thiosemicarbazone, (A9CTSC) have been prepared and characterized. Square-planar geometry has been assigned to all these complexes, although the Cu(II) chelate exists in a dimeric form. A9CTSC acts as a monovalent bidentate ligand in all these
complexes using the donor sites azomethine nitrogen and thiolate
sulphur atoms. The thermal decomposition kinetics and mechanism
of these chelates were studied from thermogravimetric data. The
kinetic parameters, namely activation energy, E, pre-exponential
factor, A, and entropy of activation, ΔS, were calculated from the
TG and DTA curves using mechanistic and nonmechanistic integral
equations. The ligand and Cu(II) complex were screened for their
possible antitumour activity and the chelate was appreciably active
in reducing mice tumours. X-ray diffraction pattern of one of the
chelate [CdL₂] was examined and successfully indexed.