Effect of Chelation on Antifungal Activity of Norfloxacin
Corresponding Author(s) : Pramila Singh
Asian Journal of Chemistry,
Vol. 14 No. 3 (2002): Vol 14 Issue 3
Abstract
Complexes of norfloxacin, an antibiotic drug with some transition elements, have been prepared and evaluated for their antifungal activity. The complexes of Fe(III), Ni(II) and Cu (II) have been characterized on the basis of analytical data, conductance, magnetic susceptibility measurements and spectral data. When complexes
were tested for antifungal activity differences were observed between
complex and free ligand (drug). The stoichiometry of the
complex has been found to be 1 : 2 for Cu(II) where as Ni(II) and
Fe(III) complexes show 1 : 1 stoichiometry with chloride or acetate
ion in the coordination sphere. The complexes are of the general
formulae CuL2.(H2O)2 and MLR (H2O);. [where R = CH3COO– for
Ni(II) and Cl– for Fe(III), L = norfloxacin, M = Cu(II), Ni(II),
Fe(III)].
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