Synthesis and Antifungal Activity of 2-Phenylimino-5-Aryl/ Alkylimino-1,3,4-Thiadiazolidines

Abstract

Synthesis of several 2-phenylimino-5-aryl/alkylimino-1,3,4-thiadiazolidines (IV) have been reported by a new route. The interaction of aryl/alkyl thiosemicarbazides (I) and N-phenyl isocyano dichloride (II) in refluxing chloroform medium for 3 h afforded 2-phenylimino-5-aryl/alkylimino-1, 3, 4-thiadiazolidines hydrochlorides
(III) which on basification with dilute ammonium hydroxide
solution gave title compounds (IV). Title compunds on
acetylation in 1 : 1 ratio gave monoacetyl derivatives (V). The structures
of all these compounds were established on the basis of elemental
analysis, equivalent weight determination and IR and PMR
spectal studies. The synthesized compounds were assayed for their
antifungal activity against tuber fungus Rhizoctonia bataticola with
encouraging results.