Metal-Chelation and Biological Activity

Abstract

Importance of chelation of multidentate donors with biologically important metal ions has been emphasized in this work. As metal ions involve practically in phases of biological activity, hence this work throws light on useful information for elucidating the various types of mechanism in biological systems. Thus chelate compounds
of the general formula (ML)₂L¹ where M = Na, K, Mg and Ca;
L = deprotonated organic acids like lactate and oxalate ions
L´= o-carboxyl-bis-benzene-azo-resorcinol and o-nltro-bis-benzene-
azo-resorcinol have been synthesised and studied to develop
innovative strategies for preparing improved and better complexes
in the light of chelate hypothesis.