Synthesis and Antibacterial Activity of 1,5-Benzothiazepine Derivatives

Abstract

Several new 2-substituted aryl-4-[2´-hydroxy-4´-(p-trifluoro-methyl/nitro-phenoxy)-phen-1´-yl)-dihydro-1,5-benzothiazepines (II) have been prepared by reaction of 1-[2´-hydroxy-4´-(p-trifluoromethyl/nitro-phenoxy)-phen-1´-yl)-3-substituted aryl-2-propen-1-ones(I) with 2-amino-thiophenol in ethanol. Few of these compounds are characterised by IR and NMR spectra. All these synthesized 1,5-benzothiazepines have been screened against a few microorganisms for antibacterial activity.