Alcyonacean Metabolites VIII-Antibacterial metabolites from Labophytum crassum of the Indian Ocean

Abstract

Bioassay guided fractionation of the ethyl acetate soluble fraction of the soft coral Lobophytum crassum yielded a cembranoid diterpene [(7E, 11E,1R,2S,3R,4R,14S)-14-acetoxy-3,4-epoxycembra-7,11,15-triene-17,2-olide, 1] as the potent anti-bacterial metabolite exhibiting activity against Pseudomonas aeroginosa, Staphylococcus
epidermis, Staphylococcus aureus and Bacillus subtilis. A
new ceramide (2) with moderate antibacterial activity besides two
known polyhydroxysterols and batyl alcohol were also isolated.