Spectrophotometric Determinations of Pimozide and Mefloquine Hydrochloride through Ion Association Complex Formation

Abstract

Three simple spectrophotometric methods (Method A, Method B and Method C) have been developed for the determination of pimozide (PZ) and mefloquine hydrochlonde (MQ) in bulk and pharmaceutical formulations. These methods are based on the formation of ion association complex involving tertiary nitrogen of PZ or secondary nitrogen of MQ and dye
[wool fast blue BF (WFB BF, λ_max 580 nm, method A); naphthol blue
black (NBB, λ_max 580 nm, method B); supracen violet 3B (SV 3B, λ_max
560 nm, method C]. Beer's law limits, precision and accuracy of these
methods are checked by the UV reference method. The results obtained
are reproducible and are statistically validated and so found to be suitable
for the assay of PZ or MQ in bulk and pharmaceutical formulations.