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Vol. 14 No. 2 (2002): Vol 14 Issue 2

Simple Oxidimetric Methods for Determination of Stavudine or Lamivudine

C.S.N. Sarma
Department of Physical, Nuclear and Chemical Oceanography, School of Chemistry, Andhra University, Visakhapatnam-530 003, India
C. Kamala Sastri
Department of Physical, Nuclear and Chemical Oceanography, School of Chemistry, Andhra University, Visakhapatnam-530 003, India
C.S.P. Sastri
Department of Physical, Nuclear and Chemical Oceanography, School of Chemistry, Andhra University, Visakhapatnam-530 003, India

Corresponding Author(s) : C.S.P. Sastri

Asian Journal of Chemistry, Vol. 14 No. 2 (2002): Vol 14 Issue 2

Abstract

Three simple and sensitive visible spectrophotometric methods (A, B and C) have been described for the estimation of stavudine (STU) or lamivudine (LAM) in pure state and in unit dosage forms. These are based on the oxidation of STU or LAM with oxidant (potassium permanganate. MnO–4, method-A; potassium permanganate-
sodium metaperiodate, MnO–4-IO–4, method-B; ferric
chloride. Fe(III), method-C), followed by the estimation of unreacted
oxidant with fast green FCF (FG FCF, method-A) or product
formed [aldehyde with 3-methyl benzothiazolinone hydrazone
(MBTH), method-B; Fe(II) with potassium ferricyanide
[Fe(CN)6]3–, method-C. The variable parameters of all these
methods have been optimised and the chemical reactions involved
are presented. The results obtained in these methods are statistically
validated and recoveries range from 99.07 to 99.95%

Keywords

Lamivudine Oxidimetric Determination Methods Stavudine
Sarma, C., Kamala Sastri, C., & Sastri, C. (2010). Simple Oxidimetric Methods for Determination of Stavudine or Lamivudine . Asian Journal of Chemistry, 14(2), 683–690. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/22137
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