Synthesis, Characterization and Antimicrobial Activity of Some New Thiosemicarbazones

Abstract

Four different thiosemicarbazones, viz., m-anisaldehyde thiosemicarbazone (1a), acetophenone-thiosemicarbazone (2a), 2-hydroxy-5-methyl benzene-1,3dicarbal thiosemidicarbazone (3a) and 2,6-diacetyl-pyridine thiosemidicarbazone (4a) have been synthesized by the reaction of different
carbonyl compounds with thiosemicarbazide (a) and were characterized
by their TLC, elemental analysis and IR spectral data. All compounds have
been screened for their biocidal activity in vitro by serial dilution method
against gram +ve bacteria Staphylococcus aureus and gram -ve Escherichia
coli and two common fungi Aspergillus niger and Aspergillus
flavus. All the thiosemicarbazones have shown several-fold increase in
antimicrobial activity as compared to their constituting thiosemicarbazide
and carbonyl compounds.