Synthesis of Some New Chlorostituted Pyrazolines and Their Curative Effect on Induced Hepatotoxicity in Albino Rat

Abstract

Chlorosubstituted 4-aroyl-Δ²-pyrazolines (2a-d) were synthesized by
condensing chlorosubstituted 3-aroylflavanones (1a-d) with phenylhydrazine
hydrochloride in DMSO containing a little piperidine and assayed
these compounds (2a-d) on cythion induced activities in albino rats with
special reference to blood serum (VLDL, LDL and HDL) hepatotoxicity.
The effects of intraperitonial administration of 4-aroyl-Δ²-pyrazolines
(100mg/kg body wt.) were studied on cythion induced blood serum hepatotoxicity.
The blood serum VLDL, LDL and HDL were estimated in
order to assess the liver functions by established procedures. Biochemical
observations were supplemented with histological examination of liver
section. It is evident from the results that the levels of serum lipoproteins
were more altered in cythion treated animals than controls. There was small
but significant decrease in the concentration of total serum lipids which
may be largely due to the reduction of the total lipid concentration in the
VLDL, LDL and HDL. However, the altered lipoprotein concentration
levels were restored to almost normalcy in 4-aroyl-Δ²-pyrazolines treated
animals.