HPLC Method for the Estimation of Nicorandil in Pharmaceutical Dosage Forms
Corresponding Author(s) : Y.S.R. Krishnaiah
Asian Journal of Chemistry,
Vol. 15 No. 3 (2003): Vol 15 Issue 3
Abstract
A reverse phase high pressure liquid chromatographic method (HPLC)
has been developed for the estimation of nicorandil in its tablet dosage
forms using RP-C18 column. The mobile phase (acetonitrile and 0.02 M
potassium dihydrogen orthophosphate)-was pumped at a flow rate of 0.8
mL/min in the ratio 40 : 60, and the eluents were monitored at 254 nm.
The intra- and inter-day variation was found to be less than 2.5% showing
high precision of the assay method. The mean recovery of the drug from
the Solutions containing 4 or 6 μg/mL was 99.83 ± 0.2% indicating high
accuracy of the proposed HPLC method. Due to its simplicity, rapidness,
high precision and accuracy, the proposed HPLC method may be used for
determining nicorandil in bulk drug samples or in tablet dosage forms.
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