Extractive Spectrophotometric Determination of Gatifloxacin

Abstract

Three simple and sensitive extractive spectrophotometric methods
(A-C) have been developed for the determination of
gatifloxacin (GTL) in bulk drug and pharmaceutical formulations.
The developed methods involve formation of coloured chloroform
extractable complexes of drug with wool-fast blue BL (WFB BL
λ_max 590 nm, Tropaeolineooo (TP_ooo,  λ_max 480 nm) and bromo
phenol blue (BPB  λ_max 420 nm) in acidic medium. Beer's law is
obeyed in the concentration ranges of 1-6  μg/mL, 1-6  μg/mL and
2-10  μg/mL respectively. The results of analysis for all three methods
have been validated statistically and by recovery studies.