Simple Oxidimetric and High Performance Liquid Chromatographic Methods for the Determination of Pantoprazole
Corresponding Author(s) : D.G. Sankar
Asian Journal of Chemistry,
Vol. 15 No. 2 (2003): Vol 15 Issue 2
Abstract
Three simple and sensitive methods (A, B & C) have been described
for the estimation of pantoprazole (PTP) in bulk samples and pharmaceutical
formulations. Methods A and B are spectrophotometric methods based
on the oxidation of PTP with oxidant (potassium permanganate,
MnO4-, A; ferric chloride, Fe(III), B) followed by estimation of unreacted
oxidant with Fast Green FCF (FGFCF, A) or reduced form of oxidant
[Fe(II)] with potassium ferricyanide ([Fe(CN)6]3-, B). Method C is a
HPLC method in which C18 column with a mobile phase consisting of
acetonitrile and water (60 : 40) and beclomethasone dipropionate as an
internal standard were utilised. The eluents were monitored at a detection
wavelength of 289 nm. The results obtained are reproducible and are
statistically validated.
Keywords
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