Synthesis of 2-S-Tetra-O-Benzoyl-D-Glucopyranosyl-1-Aryl-5-Phenyl-2-Isothiobiurets and Their Antibacterial and Antifungal Studies
Corresponding Author(s) : S.P. Deshmukh
Asian Journal of Chemistry,
Vol. 15 No. 2 (2003): Vol 15 Issue 2
Abstract
Certain 2-S-tetra-O-benzoyl-D-glucopyranosyl-1-aryl-5-phenyl- 2-isothiobiurets have been prepared by the interaction of S-tetra-O-benzoyl- D-glucopyranosyl aryl isothiocarbarnides and phenyl isocyanate. The identities of these new compounds have been established on the basis of usual chemical transformations and IR, NMR and mass spectral studies. The compounds were screened for their antibacterial and antifungal activity against various pathogenic bacteria and fungi such as S. aureus, P. vulgaris, Pseudomonas, Bacillus, E. coli, Salmonella, Fusarium and A. niger. These compounds showed good to moderate activity against above micro-organisms. The polarimetric studies of these compounds has also been carried out.
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