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Vol. 15 No. 2 (2003): Vol 15 Issue 2

Assay of Nelfinavir Mesylate in Pharmaceutical Formulations by Visible Spectrophotometry

S.V. Murali Mohan Rao
Department of Organic Chemistry, Foods, Drugs and Water, School of Chemistry, Andhra University, Visakhapatnam-530 003, India
T. Rama Subba Reddy
Department of Organic Chemistry, Foods, Drugs and Water, School of Chemistry, Andhra University, Visakhapatnam-530 003, India
U. Viplava Prasad
Department of Organic Chemistry, Foods, Drugs and Water, School of Chemistry, Andhra University, Visakhapatnam-530 003, India
C.S.P. Sastry
Department of Organic Chemistry, Foods, Drugs and Water, School of Chemistry, Andhra University, Visakhapatnam-530 003, India

Corresponding Author(s) : C.S.P. Sastry

Asian Journal of Chemistry, Vol. 15 No. 2 (2003): Vol 15 Issue 2

Abstract

Three simple and sensitive visible spectrophotometric methods


 


(A-C) for the determination of nelfinavir mesylate (NEL) in bulk


 


and pharmaceutical formulations are described. Methods A and B


 


are based on the formation of ion-association complexes between


 


NEL and wool-fast blue BL (WFB BL,  λmax 590 nm) or Tropaeolen


 


000 (TP 000,  λmax 480 nm). Method C is based on the formation


 


of diazo coupling product of NEL with diazotized p-nitroaniline


 


(DPNA,  λmax 480 nm). Regression analysis of Beer's law plots


 


showed good concentration ranges (0.5-5.0, 1.9-20 and 2.0-25)


 


μg/mL for methods A, B and C respectively.

Keywords

Extractive Spectrophotometric determination Nelfinavir Mesylate
Murali Mohan Rao, S., Rama Subba Reddy, T., Viplava Prasad, U., & Sastry, C. (2010). Assay of Nelfinavir Mesylate in Pharmaceutical Formulations by Visible Spectrophotometry. Asian Journal of Chemistry, 15(2), 971–976. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/21731
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