Synthesis, Characterization and Antibacterial Activity of Some Schiff Bases of 2-Amino-3-(N-Tolyl Carboxamido)-4,5-Pentamethylene Thiophenes
Corresponding Author(s) : J. Saravanan
Asian Journal of Chemistry,
Vol. 15 No. 2 (2003): Vol 15 Issue 2
Abstract
2-Amino-3-(N-tolyl carboxamido)-4,5-pentamethylene thiophenes
(I-III) were synthesized by Gewald reaction. Later, the compounds I-III
were treated with ten different substituted arylaldehydes to yield thirty new
Schiff bases (Ia-j to IIIa-j). The compounds were characterized by spectral
data and were screened for antibacterial activity. Some of these Schiff
bases exhibited interesting activity.
Keywords
Synthesis
Thiophenes
Schiff bases
Antibacterial activity
(1)
Mohan, S.; Saravanan, J. Synthesis, Characterization and Antibacterial Activity of Some Schiff Bases of 2-Amino-3-(N-Tolyl Carboxamido)-4,5-Pentamethylene Thiophenes . ajc 2010, 15, 625-628.
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