Synthesis of Some Diimidazolin-5-One Carboxamide Derivatives of 1,4-Dihydropyridine as Possible Antifungals and Insecticidals

Abstract

Diimidazolin-5-one carboxamide derivatives of 1,4-dihydropyridine
were prepared in three steps: 1,4-dihydro-2,6-dimethyl-4-(aryl-substituted/2-
furyl) pyridine-3,5-dicarboxylic acid dimethyl ester (I) were prepared
by condensing methyl acetoacetate, aromatic aldehydes and ammonia
in the presence of ethanol. (I) on treatment with hydrazine hydrate gave
1,4-dihydro-2,6-dimethyl-4-(aryl-substituted/2-furyl) pyridine-3,5-dihydrazide
(ll), (II) on treatment with 4-benzylidene-2-phenyloxazol-5-one/4-
furalidene-2- phenyloxazol-5-one in the presence of anhydrous pyridine
gave 1,4-dihydro-2,6-dimethyl-4-(aryl-substituted/2-furyl) pyridine-3,5-
di- [N-( 4-(benzylidene substituted/furalidene)-2-phenyl imidazolin-5-one)
carboxamide) (III).