Novel Bioactive Thio- and Semi-carbazide Ligands and Their Organotitanium(IV) and Organozirconium(IV) Complexes

Abstract

Organotitanium(IV) and organozirconium(IV) complexes have
been synthesized by the reaction of titanocenedichloride or zirconocenedichloride
with two different ketimines in the presence of
triethylamine. In all the reactions the imines behave as monobasic
bidentate ligands. The resulting complexes Cp₂M(L)(L') [where
Cp = cyclopentadienyl ring, L = 2-[1-(2-thienyl)ethyledene]hydrazine-
carbothioamide and L' = 2-[1-(2-thienyl)etbyledene]hydrazinecarboxamide,
2-[ 1-(2-naphthenyl)etbyledene ]hydrazinecarbothioamide,
and 2-[1-(2-naphthenyl)etbyledene ]hydrazinecarboxamide
have been characterized by elemental analysis and IR
and  ¹H NMR spectral studies. Based on these spectral studies, an
octahedral structure has been proposed for all the complexes. The
antifungal, antibacterial and antifertility activities of the ligands and
their complexes have also been carried out.