Synthesis of Derivatives of 3-Phenyl-2H-Pyrano[2,3-b] Quinoline-2-Ones and Comparison of Their Biological Activities

Abstract

Synthesis of a series of title compounds including several hitherto
unknown derivatives of 3-phenyl-2H-pyrano (2,3-b) quinoline-
2-ones (3) is reported by the Perkin type reaction of
3-formyl-2-quinolones (2) with sodium salt of phenylacetic acid,
The 3-formyl-2-quinolones inturn were obtained from 2-chloro-3-
formylquinolines (1). Structures of all the products have been established
by spectral and elemental analysis data. Biocidial activities
have been tested in vitro.