Synthesis and Antimicrobial Activities of Some Substituted Pyrimidines and Pyrimidinothiocarbamides

Abstract

In this paper, guanidine carbonate was interacted with acetoacetic ester to synthesize 2-amino-4-hydroxy-6-methyl pyrimidine (I), which on further treatment with phenylisothiocyanate and methyl-isothiocyanate gave 1-(4-hydroxy-6-methyl pyrimidino)-3-phenyl thiocarbamide (Ia) and 1-(4-hydroxy-6-methyl pyrimidino)-3-methyl thiocarbamide (Ib). Similarly interaction of guanidine carbonate was carried out with ethyl-α-benzyl-β-keto butyrate to synthesize 2-amino-4-hydroxy-5-benzyl-6-methyl pyrimidine (II), which on further reaction with phenylisothiocynate and methylisothiocyanate gave 1-(4-hydroxy-5-benzyl-6-methyl pyrimidino)-3-phenyl thiocarbamide (IIa) and 1-(4-hydroxy-5-benzyl-6-methyl pyrimidino)-3-methyl thiocarbamide (IIb), respectively. The antimicrobial activities of these compounds were studied by using well diffusion assay method.