A Novel Application of Hydrotropic Solubilization in the Analysis of Bulk Samples of Ketoprofen and Salicylic Acid

Abstract

In the present investigation, hydrotropic solubilization technique has been employed to solubilize the poorly water soluble antiinflammatory drug, ketoprofen (by 2.0 M sodium benzoate, 2.0 M sodium salicylate and 2.0 M sodium acetate solutions) and the poorly water soluble keratolytic drug, salicylic acid (by 2.0 M sodium benzoate, 8.0 M urea and 1.25 M sodium citrate solutions) for their titrimetric analyses The proposed method is new, simple, accurate and reproducible. Statistical data prove the accuracy, reproducibility and precision of the proposed method.