Inhibition of Tyrosinase Activity on Dopamine Hydrochloride by Thiol Compounds

R. Sariri; Jafar Mahmoodian; Khosro Khaje; Reza Hasan Sajedi

Issue

Vol. 18 No. 1 (2006): Vol 18 Issue 1

Issue Published : 8 November 2005

Inhibition of Tyrosinase Activity on Dopamine Hydrochloride by Thiol Compounds

R. Sariri

Department of Biology, The University of Guilan, Rasht, Iran

Jafar Mahmoodian

Department of Biology, The University of Guilan, Rasht, Iran

Khosro Khaje

Department of Biology, The University of Guilan, Rasht, Iran

Reza Hasan Sajedi

Department of Biology, The University of Guilan, Rasht, Iran

Corresponding Author(s) : R. Sariri

sariri@guilan.ac.ir

Asian Journal of Chemistry, Vol. 18 No. 1 (2006): Vol 18 Issue 1
Article Published : 30 March 2010

Abstract

This paper reports inhibits of tyrosinase activity by two thiol compounds, thioglycolic acid and 2-mercapto ethanol, using dopamine hydrochloride as substrate. Both of these ––SH containing compounds inhibited tyrosinase activity in a noncompetitive way, with K_m values of 0.4050 and 0.2823 for thioglycolic acid and 2-mercaptoethanol, respectively. Other kinetic constants, V_max, K_cat, K_i were also obtained in each case.

Keywords

Inhibition 2-Mercaptoethanol Thioglycolic acid Polyphenol oxidase Tyrosinase

(1)

Sariri, R.; Mahmoodian, J.; Khaje, K.; Hasan Sajedi, R. Inhibition of Tyrosinase Activity on Dopamine Hydrochloride by Thiol Compounds. ajc 2010, 18, 337-340.

Issue

Vol. 18 No. 1 (2006): Vol 18 Issue 1

Inhibition of Tyrosinase Activity on Dopamine Hydrochloride by Thiol Compounds

Corresponding Author(s) : R. Sariri

Abstract

Keywords

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