Microwave Assisted Synthesis of Novel Azetidin-2-one and Thiazolidin-4-one Derivatives of Triazolyl Thiophene

Abstract

N-[3-(4-Amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-4,5-dimethyl thiophen-2-yl]-acetamide (Ia) and N-[3-(4-amino-5-mercapto-4-H-[1,2,4]triazol-3-yl)-4,5-dimethyl thiophen-2-yl]-benzamide (Ib) were condensed with different aromatic aldehydes to yield Schiff bases (IIa-j; IIIa-j). The Schiff bases on cyclization with chloroacetyl chloride in presence of triethyl amine furnished azetidin-2-ones (IVa-j; Va-j). The Schiff bases on cyclization with mercaptoacetic acid offered thiazolidin-4-ones (VIa-j; VIIa-j). The compounds thus synthesized in good yields by microwave irradiation method and were characterized by their TLC, chemical analysis and spectral data. The title compounds were subjected to antimicrobial and antitubercular activities.