Synthetic Route for Racemic Synthesis of Trans-(1R,S, 3R,S)-2-methylene-1,3-dithiane-1,3- dioxide and Reactivity with N-carbethoxy-1,2-dihydropyridine as a Dienophile
Corresponding Author(s) : Zeynep Gultekin
zeguln@yahoo.com, zpgul5@hotmail.com
Asian Journal of Chemistry,
Vol. 18 No. 2 (2006): Vol 18 Issue 2
Abstract
Trans-(1R,S, 3R,S)-2-methylene-1,3-dithiane-1,3-dioxide has been prepared in 22% yield in three steps and cycloaddition of (4a) with N-carbethoxy-1,2-dihydropyridine gave a moderate diastereoselective (76 : 24) in 20% yield. All the major compounds (4b) and (7a) were determined by X-ray analysis.
Keywords
Chiral ketene equivalents
[4 2] Cycloaddition
1,3-Dithiane
Bicyclic ketones
(1)
Gultekin, Z.; Bayrak, H.; Frey, W. Synthetic Route for Racemic Synthesis of Trans-(1R,S, 3R,S)-2-Methylene-1,3-Dithiane-1,3- Dioxide and Reactivity With N-Carbethoxy-1,2-Dihydropyridine As a Dienophile. ajc 2010, 18, 1474-1480.
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