Palladium-Catalyzed Synthesis of 9-(2-Cyclopentenyl) Guanine
Corresponding Author(s) : Zeynep Gultekin
zeguln@yahoo.com, zpgul5@hotmail.com
Asian Journal of Chemistry,
Vol. 18 No. 2 (2006): Vol 18 Issue 2
Abstract
The racemic synthesis of the 9-(2-cyclopentenyl) guanine (4) from 2-cyclopentenon was prepared in 4 steps with a good yield (43%) and excellent selectivity (N9-isomer). The syntheses were achieved in a convergent and direct manner via palladium(0) catalysed coupling between 2-amino-6-chloropurine and 2-cyclopentene-1-ethylcarbonate (2). Compounds 2–4 have been characterized by high resolution MS, 1H NMR and IR.
Keywords
Carbocyclic nucleosides
Carbovir
Purines
Gultekin, Z. (2010). Palladium-Catalyzed Synthesis of 9-(2-Cyclopentenyl) Guanine. Asian Journal of Chemistry, 18(2), 1462–1466. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/21172
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