Synthesis and Antihypercholesterolemic Activity of α-Alkyl Substituted Indan-1-acetic acids

Abstract

Non-methoxy and methoxy indan derivatives having alkyl groups at the α-carbon atom of acetic acid moiety were synthesized from their respective indan-1-acetic acids. The chemical structures of the synthesized compound were confirmed by spectral analysis. The synthesized compounds on screening for antihypercholesterolemic activity in male albino Charles Foster rats were used in this study. It has been observed that the pharmacological activity of the synthesized compounds decreases on increasing the α-alkyl chain.