Antidiarrhoeal Activity of Terminalia catappa Linn. Leaf Extracts in Rats
Corresponding Author(s) : VRUSHABENDRA SWAMY B.M.
swamybm@yahoo.com
Asian Journal of Chemistry,
Vol. 18 No. 2 (2006): Vol 18 Issue 2
Abstract
The methanol, water and petroleum ether extracts of Terminalia
catappa Linn were screened for their antidiarrhoeal potential at dose
level of 1/5th of their lethal doses screened against several experimental
models of diarrhoea in rats. The methanol and aqueous
extracts showed significant inhibitory activity against castor oil
induced diarrhea and inhibited PGE2 induced enteropooling in rats.
The methanol and aqueous extracts also showed significant reduction
in gastrointestinal motility following charcoal meal in rats.
Keywords
Antidiarrhoeal Activity
Terminalia catappa.
Methanol
Aqueous extracts
PGE2
Castor oil
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SWAMY B.M., V.; MANSOORAHMED, S.; GoPKUMAR, P.; DHANAPAL , R.; CHANDRASHEKAR, Y.; SREENIVAS RAO, T. Antidiarrhoeal Activity of Terminalia Catappa Linn. Leaf Extracts in Rats. ajc 2010, 18, 1236-1242.
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