Novel Synthesis and Antimicrobial Activity of 3,7-Dimethyl phenoxathiin Nucleus and Some Related Analogues

Abstract

The synthesis of important precursor to biologically active compounds, 3,7-dimethyl phenoxathiin, is described using a new approach involving aromatic dihydroxy ditolyl sulphone intermediate. Synthesis of the same target in addition to some mono and dimethyl substituted phenoxathiin derivatives by alternative methods is also reported. The antibacterial and antifungal properties of all prepared substituted methyl phenoxathiins and their oxidized derivatives have been evaluated against assortment of microorganisms. The oxidized derivatives of the methyl and the dimethyl phenoxathiins showed weak in-vivo antifungal activity, whereas the non-oxidized derivatives showed negligible antimicrobial activity.