Resolution of (1RS, 3RS)-2-N,N´ -Dimethyl-aminomethyl-1,3 dithiolane-1,3-dioxide Using Optically Active Acids
Corresponding Author(s) : Zeynep Gultekin
zeguln@yahoo.com
Asian Journal of Chemistry,
Vol. 18 No. 3 (2006): Vol 18 Issue 3
Abstract
Racemic (1RS,3RS)-2-N,N´-dimethylaminomethyl-1,3-dithiolane-1,3-dioxide is resolved by formation of salts with chira1 acids [such as (1S)-(+)-10-camphorsulphonic acid, (-)-dibenzoyl-L-tartaric acid, (R)-(-)mandelic acid]. The best solvent for recrystallization of the diastereomeric mixture is found to be propionitrile and gave 68% ee.
Keywords
Cbiral amines
Dithiane
Diastereomeric resolution
(1)
Gultekin, Z. Resolution of (1RS, 3RS)-2-N,N&Acute; -Dimethyl-Aminomethyl-1,3 Dithiolane-1,3-Dioxide Using Optically Active Acids. ajc 2010, 18, 1867-1870.
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX