New Imidazole Compounds Derived from Pyrrolidonic and Piperidonic Acids as Non- Steroidic Aromatase Inhibitors
Corresponding Author(s) : Valeric Rolland
rolland@univ-montpz.fr
Asian Journal of Chemistry,
Vol. 18 No. 3 (2006): Vol 18 Issue 3
Abstract
Imidazole and indole compounds derived from pyrrolidine and piperidine carboxylic acids are synthesized and characterized. The inhibition activity of those compounds was evaluated in-vitro on aromatase extracted from human placenta, compared to the first representative non-steroid agent (aminoglutethimide). Imidazoles derivatives showed significant inhibition of aromatase (Ki < 78.0 mM).
Keywords
Pyrrolidonic
Piperidonic acids
Aromatase inhibitors
Tabcheh, M., Baroudi, M., Elomar, F., Elzant, A., Elkhatib, M., & Rolland, V. (2010). New Imidazole Compounds Derived from Pyrrolidonic and Piperidonic Acids as Non- Steroidic Aromatase Inhibitors. Asian Journal of Chemistry, 18(3), 1771–1782. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/20876
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