New Imidazole Compounds Derived from Pyrrolidonic and Piperidonic Acids as Non- Steroidic Aromatase Inhibitors
Corresponding Author(s) : Valeric Rolland
rolland@univ-montpz.fr
Asian Journal of Chemistry,
Vol. 18 No. 3 (2006): Vol 18 Issue 3
Abstract
Imidazole and indole compounds derived from pyrrolidine and piperidine carboxylic acids are synthesized and characterized. The inhibition activity of those compounds was evaluated in-vitro on aromatase extracted from human placenta, compared to the first representative non-steroid agent (aminoglutethimide). Imidazoles derivatives showed significant inhibition of aromatase (Ki < 78.0 mM).
Keywords
Pyrrolidonic
Piperidonic acids
Aromatase inhibitors
(1)
Tabcheh, M.; Baroudi, M.; Elomar, F.; Elzant, A.; Elkhatib, M.; Rolland, V. New Imidazole Compounds Derived from Pyrrolidonic and Piperidonic Acids As Non- Steroidic Aromatase Inhibitors. ajc 2010, 18, 1771-1782.
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX