Microwave Assisted Synthesis and Characterization of Some New Isatin Derivatives

Abstract

3-[(5-Benzylidene-2-phenyl)-3,5-dihydro-4H-imidazol-4-one-3-(4-benzoylhydrazono)]- indole-2-ones (IV) were synthesized in high yield (82%) using a microwave method. In these, different isatin hydrazones (II) are reacted with 2-phenyl-5 bezylidene-3-N-(4-acetyl phenyl)-1,5-dihydro-imidazol-4-one to afford final compound (IV). Synthesis of 3-[(5- benzylidene-2-phenyl)-3,5 dihydro-4H-imidazol-4-one-3-(4-benzoyl hydrazono)]- indole-2- ones (IV) was found much easier and faster than conventional heating method. These compounds were characterized by IR, ¹H NMR and mass spectra.