Visible Spectrophotometric Determination of Aceclofenac in Tablet Formulation

Abstract

Two simple, economical, precise, convenient and reproducible visible spectrophotometric methods have been developed for the estimation of aceclofenac in tablet formulation. The developed methods are based on the formation of chloroform extractable complex of aceclofenac with orange G in acidic medium and naphthol green in aqueous medium. The extracted complex with orange G shows absorbance maxima at 481 nm and linearity in the concentration range of 10-80 mcg/mL. The extracted complex with naphthol green shows absorbance maxima at 633.6 nm and linearity in the concentration range of 0.2-1.0 mg/mL. Results of analysis for both the methods were validated statistically and by recovery studies.