Synthesis of Some New N'-[5'-(N10-Phenothiazinomethyl)-1',3',4'-thiadiazol-2'- yl] N-aryl guanidine hydrochlorides with Possible Antithyroid Activity
Corresponding Author(s) : Gir Raj Singh
Asian Journal of Chemistry,
Vol. 18 No. 4 (2006): Vol 18 Issue 4
Abstract
Several new N´-[5´-(N10-phenothiazinomethyl)-1´,3´,4´-thiadia-zol-2´-yl] N-aryl guanidine hydrochlorides (I) have been synthesized by the reaction of 2-amino-5-(N10- phenothiazinomethyl)-1,3,4-thiadiazole with different aryl cyanamides. All these synthesized aryl guanidines have been screened for their antithyroid activity. The compounds were characterised by elemental analysis, IR and NMR spectra.
Keywords
Synthesis
N-Aryl guanidines
Antithyroid activity
(1)
Raj Singh, G.; C. Mehra, S. Synthesis of Some New N’-[5’-(N10-Phenothiazinomethyl)-1’,3’,4’-Thiadiazol-2’- Yl] N-Aryl Guanidine Hydrochlorides With Possible Antithyroid Activity. ajc 2010, 18, 3132-3134.
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX