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Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

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Design, Sustainable Synthesis, Characterization, Antimicrobial Evaluation and in silico ADMET Prediction of New Functionalized Imidazolium Based Ionic Liquids

https://doi.org/10.14233/ajchem.2020.22747
Anas R. Al Johani
Department of Chemistry, Taibah University, 30002, Al-Madina Al-Mounawara, Saudi Arabia
Saud M. Almutairi
King Abdulaziz City for Science and Technology, Riyadh 11442, P.O. Box 6086, Saudi Arabia
Wael S. El-Sayed
Department of Microbiology, Faculty of Science, Ain Shams University, Cairo11566, Egypt
Pramod K. Sahu
School of Study in Chemistry, Jiwaji University, Gwalior-474011, India
Praveen K. Sahu
Department of Industrial Chemsitry, Jiwaji University, Gwalior-474011, India
Mouslim Messali
Department of Chemistry, Taibah University, 30002, Al-Madina Al-Mounawara, Saudi Arabia

Corresponding Author(s) : Anas R. Al Johani

dr.aljohani.anas@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Abstract

A series of sixteen new ionic liquids (ILs) bearing imidazolium moiety were designed and synthesized under sustainable and green conditions which were confirmed by analytical and  spectral techniques using 1H- & 13C-NMR, FT-IR, mass and elemental analysis. A panel of clinically isolated strains was used for in vitro inhibitory antimicrobial activities screening of  synthesized ionic liquids. The results of antimicrobial assay showed that some of synthesized ionic liquids showed moderate to good activity. Among these ILs, ionic liquids 3, 4 and 5  (bearing alkyl chain with a phenyl group) significantly inhibited cell growth of strains. In this regard, these ionic liquids considered as promising antibacterial agents when compared with  standard antibiotics. By encouraging in vitro antimicrobial screening, in silico ADMET evaluation has been performed and found excellent pharmacokinetic, bioavailability and toxicity profiles.  Synthesized ionic liquids has found to be safe and non-toxic according to calculated in vivo computed LD50 values (2.49-2.80 mg/kg) for rat acute toxicity.

Keywords

Functionalized immidazolium Ionic liquids ADMET Antimicrobial assay
Al Johani, A. R. ., Almutairi, S. M. ., El-Sayed, W. S. ., Sahu, P. K. ., Sahu, P. K. ., & Messali, M. . (2020). Design, Sustainable Synthesis, Characterization, Antimicrobial Evaluation and in silico ADMET Prediction of New Functionalized Imidazolium Based Ionic Liquids. Asian Journal of Chemistry, 32(8), 1972–1980. https://doi.org/10.14233/ajchem.2020.22747
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