Synthesis and Anticonvulsant activity of New 2-(Substituted aryl/heteryl)-3-(substituted arylidenimino)-6, 8-dibromo-1,2,3,4-tetrahydroquinazolin-4(3H)-one Derivatives

Abstract

Methyl-3,5-dibromo anthranilate was methylated from 3,5-dibromo anthranilic acid and converted to 3,5-dibromo anthranil hydrazide by reacting with hydrazine hydrate. The hydrazide was condensed with the different p- and m-substituted aromatic aldehydes in presence of alcohol and concentrated hydrochloric acid to get the 2-(substituted phenyl/heteryl)-3-(substituted arylidenimino)-6,8-dibromo-1,2,3,4-tetrahydroquinazolin- 4(3H)-one derivatives (4-14). The structures of all the synthesized compounds have been confirmed by sup ¹H NMR and mass spectral data. All the synthesized compounds were screened for anticonvulsant activity by ICES test method using phenytoin as standard drug. The test compounds 5 and 14 increase seizure threshold current statistically indicating that they are highly significantly (p < 0.001) different from control group, whereas all the compounds showed moderate activity in comparison to standard drug.