Synthesis and Antibacterial Activity of Some 4-Substituted-2-phenyl oxazol-5(4H)-one Derivatives

Abstract

A series of eight compounds of the class 4-substituted-2-phenyl oxazol-5(4H)-one was synthesized using benzoyl glycine as the starting compound. Condensation of eight different aldehydes was effected by refluxation with benzoyl glycine for different optimum periods in acetic anhydride media in presence of freshly fused sodium acetate. The synthesized compounds were characterized by UV, IR and NMR spectrometric methods. All the synthesized compounds were allowed to undergo antibacterial testing by agar dilution method. Some of the compounds showed appreciable activity on certain organisms.