Synthesis and Biological Activities of Some Oxazolo- and Oxothiazolo Pyrimidines

Abstract

A series of pyrimidine derivatives 2a-i and 3-5 were synthesized and their antimicrobial activities determined. These synthesized compounds were tested in vitro against Escherichia Coli (PTCC 1338), Pseudomonas aeruginosa (PTCC 1074), Enterococcus faecalis (PTCC 1237) and Staphylococcus aureus (PTCC 1 H 9) bacteria. Microbiological results showed that only compound 5 containing an oxazepino ring was the active pyrimidine derivative against the E. faecalis and S. aureus bacteria with a MIC value of 128 μg/mL and 64 μg/mL respectively. However, the pyrimidines fused to a thiazole or ozazole ring; 2, 3 and 4 were not active against these bacteria.