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Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

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Microwave-Assisted Synthesis of 2-(5-(5-(4-Substituted phenyl)-2-(5-methoxy-2H-chromen-3-yl)-1H-imidazol-1-yl)alkyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione Derivatives and their Antimicrobial Activity

https://doi.org/10.14233/ajchem.2020.22445
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
K. Ramakrishna
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
Nalaparaju Nagaraju
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
Ravinder Dharavath
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
M. Ram Reddy
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
M. Sarasija
Department of Chemistry, Satavahana University, Karimnagar-505001, India

Corresponding Author(s) : D. Ashok

ashokdou@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

Abstract

A method for the synthesis of several imidazoles containing isoquinoline scaffolds under conventional and microwave irradiation methods. In the microwave irradiation method gives higher yields with in shorter reaction time as compared to conventional heating method, using green solvents and eco-friendly reaction conditions. All the synthesized derivatives were characterized by IR, NMR and Mass spectral analysis. Furthermore, the title compounds were screened for their in vitro antimicrobial activity against bacteria such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia as well as fungi such as Aspergillus niger, Aspergillus flavus and Fusarium oxysporum. The compounds 8a, 8d, 8e and 8h exhibited better antimicrobial activity against all organisms.

Keywords

Imidazole Isoquinoline Microwave irradiation Antimicrobial activity
Ashok, D., Ramakrishna, K., Nagaraju, N., Dharavath, R., Reddy, M. R., & Sarasija, M. (2020). Microwave-Assisted Synthesis of 2-(5-(5-(4-Substituted phenyl)-2-(5-methoxy-2H-chromen-3-yl)-1H-imidazol-1-yl)alkyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione Derivatives and their Antimicrobial Activity. Asian Journal of Chemistry, 32(4), 839–844. https://doi.org/10.14233/ajchem.2020.22445
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