Synthesis and Antioxidant Activity of Some 2-Amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes

Abstract

A new series of 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes was synthesized by the condensation of 3-(dimethylamino)phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. The assignments of the structure of all the newly synthesized compounds were based on elemental analysis and spectral data (IR, Mass, ¹H NMR). The antioxidant activity of the synthesized compounds was determined by Ferric Reducing Antioxidant Power (FRAP) and DPPH free radical scavenging methods. Several compounds showed significant antioxidant activity.