Synthesis, Characterization and Biological Evaluation of Cobalt(II), Nickel(II) and Copper(II) Complexes of Schiff Base

Abstract

A new Schiff base ligand, 4-[{[4-(benzyloxy)phenyl]-imino} methyl]benzene-1,3-diol (bmbH), has been synthesized by the condensation reaction of p-benzyloxyaniline with 2,4-dihydroxybenzaldehyde in EtOH solution at boiling point. A mononuclear complexes of bmbH bidentate schiff base ligand with Co(II) acetate, Ni(II) acetate and Cu(II) acetate salts have been synthesized. All the complexes have been characterized by several techniques using elementel analyses conductivity measurements, IR and electronic spectral. ¹HNMR specrum of the bmbH ligand was also recorded. The mononuclear Co(II), Ni(II) and Cu(II) complexes of the Schiff base ligand, bmbH have a metal/ligand ratio of 1:2 and the ligand coordinates through the N and O atoms. The molar conductivities in DMF solution indicate non-electrolytic nature for the metal complexes. In addition, the ligand and its metal complexes were screened for antibacterial and antifungal activities by agar well diffusion techniques using DMF as solvent.