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Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

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Synthesis and Characterization of Piperidin-4-one Derivatives Using Green Solvent

https://doi.org/10.14233/ajchem.2020.22589
K. Hemalatha
Department of Chemistry, Justice Basheer Ahmed Sayeed College for Women (Autonomous), Teynampet, Chennai-600018, India
http://orcid.org/0000-0002-4817-1656
D. Ilangeswaran
Department of Chemistry, Rajah Serfoji Government College (Affiliated to Bharathidasan University), Thanjavur-613005, India
http://orcid.org/0000-0003-1249-1436

Corresponding Author(s) : D. Ilangeswaran

dhailangeswaran@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

Abstract

A deep eutectic solvent of glucose-urea was found to be an inexpensive and effective reaction medium in the synthesis of piperidin-4-one derivatives. In this work, 3-methyl-2,6-diphenyl piperidin-4-one (4a), 3,5-dimethyl-2,6-diphenylpiperidin-4-one (4b), 2,6-diphenylpiperidin-4-one (4c), piperidin-4-one (4d), 3,5-dimethylpiperidin-4-one (4e), 3-methyl-2,6-di(2-hydroxyphenyl)piperidin-4-one (4f), 3,5-dimethyl 2,6-di(2-hydroxyphenyl)piperidin-4one (4g) were synthesized using a deep eutectic solvent (DES) of glucose and urea with the percentage composition of 60:40. The yields of these products were 82, 78, 75, 68, 72, 70 and 70 %, respectively. The products obtained were characterized by FT-IR and 1H NMR spectroscopic techniques. A synthesis of piperidin-4-one derivatives by using this green solvent was considered to be new environmentally safe synthetic method.

Keywords

Deep eutectic solvent Piperidin-4-one derivatives Glucose-urea
Hemalatha, K., & Ilangeswaran, D. (2020). Synthesis and Characterization of Piperidin-4-one Derivatives Using Green Solvent. Asian Journal of Chemistry, 32(4), 981–984. https://doi.org/10.14233/ajchem.2020.22589
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