Synthesis and Antimicrobial Activity of Some Chalcones of 3-Acetyl Coumarin and 2-Hydroxy-1-acetonapthone

Abstract

Five chalcones were prepared by refluxing 3-acetyl coumarin with aldehydes in the presence of piperidine in ethanol and another five chalcones were synthesised by condensing 2-hydroxy-1-acetonaphthone with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. All these compounds were characterised by means of their IR, ¹H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.