Solvent Free Microwave Assisted Synthesis of Chalcones and Their Antifungal Activities

Abstract

The microwave assisted synthesis of six chalcones was carried out by condensing the piperanal and the acetophenone (unsubstituted, 4-methyl, 4-methoxy, 4-bromo, 4-nitro, 3-chloro) in presence of zinc chloride. Minor quantities of Ketol and Michael addition product were easily removed by recrystallization. The results indicated were correlated with solvent-free synthesis. The compounds have also been screened for their antifungal activities.