Oxidative Hydrolysis of Some Alkyl Substituted 1-Methyl- 2,6-diphenyl Piperidin-4-one Oximes by Pyridinium Fluorochromate: A Kinetic and Mechanistic Approach

Abstract

The rates of oxidation of a few alkyl substituted 1-methyl-2,6-diphenyl piperidin-4-one oximes (X = -H, -Me, -Et, -iPr, -3,3-diMe, -3,5-diMe) by pyridinium fluorochromate (PFC) was followed in aqueous acetic acid medium. The influence of substrates, oxidant, H⁺ ions, ionic strength and dielectric constant on the reaction rates at various temperatures was studied. The stoichiometry is 1:1 and the product of oxidation is the corresponding ketone. Activation energies and related thermodynamic parameters have been calculated and the plausible mechanism for oxidation reaction is discussed.