Synthesis, Characterization and Biological Screening of Some New Condensed N-Methyl Piperidino Thiophenes

Abstract

The synthesis of 2-amino-3-furfuryl carboxamido-6-Nmethyl piperidino thiophene (2) was synthesized via a multicomponent condensation between sulphur, N-methyl piperidin-4-one and furfuryl cyanoacetamide adapting Gewald reaction. Later the compound (2) was condensed with different substituted aryl aldehydes to yield 11 new Schiff bases (3a-3k) of this series and in second series the compound (2) was reacted with freshly prepared acid chlorides to form 4 new title compounds (3l-3p). All the 15 compounds were characterized by spectral data and were screened for antibacterial activity. Some of the compounds exhibited promising activity.