Synthesis and Antioxidant Activity of Substituted Phenylalkene Hydroxamic Acids

Abstract

A series of phenylalkene hydroxamic acids ahve been synthesized by acylation of hydroxylamine with substituted acyl chlorides of the substituted cinnamic acids. The substituted cinnamic acids were prepared from substituted benzaldehydes by emphasizing knoevengel reaction. The title compounds were screened for antioxidant activity, in vitro. Compounds A₇, A₁₀, A₁₁ exhibited most significant activity activities amongst all the evaluated compounds. Compound A₁₀ showed lowest IC₅₀ value (8.668 mM) ad A₅ showed highest IC₅₀ value (954.734 mM).