Synthesis and Antiviral Activity of Some Novel Isatin Derivatives
Corresponding Author(s) : P. Selvam
periyasamyselvam2001@yahoo.co.in
Asian Journal of Chemistry,
Vol. 17 No. 1 (2005): Vol 17 Issue 1
Abstract
Some novel Schiff's and mannich base isatin derivatives were synthesized. Their chemical structure was elucidated by means of spectral (FT-IR, 1H-NMR, MS) analysis. The synthesized compounds were screened for antiviral activity against influenza virus A and B in MDCK cells, HIV-1 (IIIB) and HIV-2 (ROD) in acutely infected MT-4 cells. All the compounds displayed cytotoxic properties in the lymphocyte cell line (MT-4) cells. Compound SPIII-5H-AC exhibits weak activity against influenza A (H3N2) virus in MDCK cells.
Keywords
Isatin
Anti-HIV activity
Influenza virus
(1)
Selvam, P.; Rajasekaran, A.; Dharamsi, A.; Laeeque Ahmed, K.; Mohammed Musthafa, S.; Poornima, K.; Pournami, K.; Murugesh, N.; Chandramohan, M.; De Clercq, E. Synthesis and Antiviral Activity of Some Novel Isatin Derivatives. ajc 2016, 17, 443-448.
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