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Vol. 17 No. 1 (2005): Vol 17 Issue 1

Determination of Association Constants of b-Cyclodextrin and b-Cyclodextrin-N-succinamate with Drugs by High Performance Liquid Chromatography

Alamdar Ashnagar
Department of Medicinal Chemistry, School of Pharmacy, Ahwaz University of Medical Sciences, Iran
Christopher J. Easton
Research School of Chemistry (RSC), Australian National University (ANU), Canberra, ACT 200, Australia
Nahid Gharib Naseri
Department of Medicinal Chemistry, School of Pharmacy, Ahwaz University of Medical Sciences, Iran

Corresponding Author(s) : Alamdar Ashnagar

aashnagar2003@yahoo.com

Asian Journal of Chemistry, Vol. 17 No. 1 (2005): Vol 17 Issue 1

Abstract

Investigation of the Hummel and Dreyer method for the estimation of stability constants by high performance liquid chromatography (HPLC) is described. Comparison of the results obtained for binding of cimetidine (2a) and 2-(p-tolyl)ethylamine (2b) to b-cyclodextrin (1a) and b-Cyclodextrin-N-succinamate (1b) by 1H NMR (300 MHz) spectroscopy and the HPLC method were studied. The results indicated that the stability constants by HPLC method are higher and more accurate, and are 431 and 470 dm3 mol-1 for (2a) and 138 and 111 dm3 mol-1 for (2b) in binding to (1a) and (1b), respectively.

Keywords

Association constants b-Cyclodextrin High performance liquid chromatography b-Cyclodextrin-N-succinamate
Ashnagar, A., J. Easton, C., & Gharib Naseri, N. (2016). Determination of Association Constants of b-Cyclodextrin and b-Cyclodextrin-N-succinamate with Drugs by High Performance Liquid Chromatography. Asian Journal of Chemistry, 17(1), 183–190. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/19750
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