Synthesis and Characterization of Biologically Significant Bis-[2-(Aryl/Furyl)-5-Carboxylic-4-Thiazolidinone]Sulfaguanidine Derivatives
Corresponding Author(s) : Manish Kumar Pataskar
Asian Journal of Chemistry,
Vol. 17 No. 1 (2005): Vol 17 Issue 1
Abstract
In the present work, some new bis-[2-(aryl/furyl}-5-carboxylic-4-thiazolidinone sulfaguanidine derivatives were prepared. In the synthesis of these compounds sulfaguanidine was refluxed with different types of aromatic aldehyde to prepare the Schiff base derivative (a). The compound (a) on reaction with thiomalic acid gives bis-[2-(aryl/furyl)-5-carboxylic-4-thiazolidinone] sulfaguanidine derivative (b). The structures of the products were characterized by IR spectral study. All the compounds were evaluated for antifungal and insecticidal activities. Some of the synthesized compounds showed good activity against fungi and insects.
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